Amitriptyline And Alcohol. Alcohol and Amitriptyline should not be used together. Combining the two can increase the effect making you excessively sleepy and reducing alertness.
Aside from increased fatigue and drowsiness when Elavil and alcohol are combined increased toxicity effects leading to overdose will be seen including alteration in the psychomotor skills of a patient. No drug alone importantly impaired psychomotor skills. Five healthy volunteers received 25 mg of amitriptyline orally preceded by one hour and followed for eight hours by oral ethanol or juice dosed to achieve and maintain blood ethanol concentrations of 800 mgl.
Acute Intoxication with Alcohol or Chronic consumption with liver damage tends to inhibit hepatic drug metabolism.
It is very important that you do not mix alcohol with this particular type of medication. The starting dose for this is 75mg. Alcohol is the bane of drug-drug interactions. Aside from increased fatigue and drowsiness when Elavil and alcohol are combined increased toxicity effects leading to overdose will be seen including alteration in the psychomotor skills of a patient.
